The small UX problems have been mentioned, but I think the biggest one is that quite often the touchscreen input mapping breaks. I think it happens especially after an accidental drag & drop trigger, on an image on a website, or on a tab. Then there is a good chance that either a) one touch input seems to be stuck so if you try to just scroll down with one touch, it does a pinch zoom instead, or b) the touch input is clamped to a part of the screen and you don't have touch input outside of that area. This is probably related to the landscape mode issue, but this is easily triggerable even when the phone is in portrait mode and rotation is disabled. I'm not sure you can do much about that, but it is a real issue because the only way to get proper input back I found so far is killing the app and restarting it.
This applies to bluetooth audio and usb audio (the latter apparently works now). It does NOT happen with built in speakers: Firefox likes to control the global volume. Example: Play any audio (e.g. https://radiomii.com/ or any app). Go to youtube in uWolf and start a video. Bam, 100% volume blasting your ears.
Not sure if MOZ_DISABLE_PULSEAUDIO=1 is really a thing (only 1 google result from last month?) but I tried os.environ["MOZ_DISABLE_PULSEAUDIO"] = "1" and it doesn't make a difference. I tried that because I assume the issue is with how firefox creates a separate stream for every tab/media.
In about:config I only saw media.default_volume but not even that seems to do anything about this behavior.
Does anyone know if there would be a way to make firefox behave?