@Vlad-Nirky I asked about this in the ubports Matrix channel some time ago, because of course I want to implement the Yubikey challenge-response thing for KeePassRX (it's supported by the underlying Rust library). I was told the OS doesn't have full integration yet, at the OS level. But as a disclaimer, I didn't actually bother trying it myself yet lol.
The Yubikey WILL be picked up as a USB device, at least, if plugged in. It shows up as an HID keyboard to make use of the pre-programmed typed password feature thingy of Yubikeys. I don't know if any of the other features of Yubikeys would work yet, though. One way to find out...